TEICHOMYCINS, NEW ANTIBIOTICS FROM ACTINOPLANES TEICHOMYCETICUS NOV. SP. I. DESCRIPTION OF THE PRODUCER STRAIN, FERMENTATION STUDIES AND BIOLOGICAL PROPERTIES F. PARENT[, G. BERETTA, M. BERTI and V. ARIOLI

A soil isolate of Actinoplanes that produces the chemically unrelated new amibiotics teichomycins A, and A2 has been proposed as a new species named Actinoplanes teichomyceticus nov. sp. (ATCC 31121). Studies of medium and fermentation conditions indicated that the highest antibiotic titers, ca 900 u/ml, are obtained in a medium containing 1 (w/v) glucose, 1 % cotton seed meal, 1 % malt extract, and 0.4% yeast extract. Both teichomycin A, and teichomycin A2 are highly active against gram-positive bacteria. Teichomycin A, shows some activity against gram-negative bacteria. Both antibiotics cured mice experimentally infected with sensitive bacteria and showed low acute toxicity. Of the two antibiotics teichomycin A2 is the more active.